UVC: Dr. Ryan Cole: Pathology: Proof is in the Blood
The inaugural Understanding Vaccine Causation Conference, convened by World Council for Health Steering Committee Member, Shabnam Palesa Mohamed, took place on Feb. 5, 2022. The WCH Law and Activism Committee brought together legal practitioners, doctors, scientists, and jab victim data and advocacy groups to explore a key question: How are jab adverse events proved?
Dr. Ryan Cole joined the Medical Panel to share his presentation, Pathology: Proof is in the Blood.
[00:00:06] Shabnam Palesa Mohamed: The Proof is in the Blood: Causation in Pathology. Dr. Cole, you have 15 to 20 minutes followed by 10 minutes of Q&A. The mic is yours.
[00:00:14] Dr. Ryan Cole: Okay. So, everybody hear me okay? Thank you, Dr. Burkhart. Your presentation was fantastic. And to answer that last question, I’m with you, the more tissue we can see and demonstrate immunohistochemically, the easier it is to find some[inaudible]. I’m actually in the morgue today, hence my really decorative background here. I’m doing a mortem in between, I got called out of state to do this.
[00:00:38] So anyway, the proof is in the blood. I think we need to look at some interesting things. Obviously around the world, I always start my talk [inaudible] General Patton. If everybody’s thinking alike, then nobody is thinking, or then somebody isn’t thinking, and, you know, with these vaccines where there’s risk, we must have choice.
[00:00:55] [Inaudible] worldwide is when we have an unapproved drug or a vaccine that’s new and experimental, all adverse reactions and death should be considered to be caused by that agent until it can be proven otherwise. We’re currently looking the other way and doing just the opposite.
[00:01:15] Shabnam Palesa Mohamed: Ryan, I apologize for interrupting. There’s been a very humble request for you to maximize your slides.
[00:01:21] Dr. Ryan Cole: Okay, very good. So if something is new, novel, we’re using it on humanity, we need to be assuming that every adverse reaction is caused by that agent. Maybe earlier, one of the attorneys [inaudible] causal association, Bradford Hill’s criteria for making causal inferences. And we look at strength of association, the dose-response relationship, the lack of moral ambiguity, consistency of the findings, the biologic plausibility, the coherence of the evidence, and then specificity of the association.
[00:01:57] So once you have enough [inaudible] then correlation is causation. And, and I think, you know, we get, oh, these are not the droids you’re looking for was just this one thing or this other thing. But when you have the aggregate of these findings and Bradford Hill’s criteria, they come, I think, strongly into play and correlating those findings into a causative relationship.
[00:02:19] One thing that’s a challenge in the lab and in what we’re doing in medicine is we get this mantra: everybody get a shot, everybody get a shot, get your shot. Most patients don’t have a baseline of blood work prior to getting a shot. So that correlation and causation, uh, could be a challenge. Now, if an employer, or if a government, or whatever agency is mandating somebody to get a shot, I think it would behoove the individual, and it would also bring a medical-legal plane of thinking into play, that if you have a baseline for numerous labs and you can indicate changes in those labs afterwards, now we’ve shifted this mandate concept onto the liability of an employer. So that’s one recommendation I have.
[00:03:03] Now, you know, personally, I think the jabs are expired, now that Omicron is here. They’re irrelevant in terms of being for the original Wuhan strain in terms of the form formulation of the shots. So it’s even pointless to mandate them for Omicron as they become ineffective. Now, the other important thing is, has the patient already had Covid? You know, there’s a two to four times adverse event risk if you’ve already had Covid by getting a shot. Many papers showing adverse events are increased. Well, this goes to basic immunology and basic levels of auto antibodies and antibody titers and T-cell activity. And then if a patient is getting a shot and they have an unknown infection present, that can lead to a lot of those tissue changes that we saw in Dr. Burkhadrt’s presentation.
[00:03:51] [Inaudible] the one, you know, we hear about most check the D-dimer, that’s a fibrin split products. That’s clotting. We know that the shots are prone to cause clotting, J and J, and that [inaudible] vectors are black box warnings on those. We need those studies, you know, what are some basic ones, not everybody around the world in different settings can get into complex lab panels, you know, basic one, the D-dimer, time and temperature sensitive in the lab. Sedimentation rate, is a very important one is pre and post shot. What’s your C-reactive protein levels. Troponin, is there a cardiac damage? Pre-mortem, in the living patients obviously. Basic CBC. You know, what are the counts doing? I’m going to get to that in a second. Your comprehensive metabolic panel, liver, et cetera. Hemoglobin A1C tends to go up after shots as well. And a lot of glucose dysregulation and kidney dysfunction, so looking at glomerular filtration rates.
[00:04:49] This paper, I think is seminal. This came out at a couple of months ago and this one goes over all the different variations we see in blood and persisting for weeks on end after the shots are given. And here I won’t go through every single one of them because it’s spelled out here, but changes in cholesterol; downregulation of electrolytes, potassium, sodium; upregulation of hemoglobin A1C, more sugar over time; cardiac enzymes going up, CK-MB, creatinine kinase, et cetera; renal function being dysregulated; liver function being off.
[00:05:26] But, you know, I’ll go back. That paper, Cell Discovery, comprehensive investigations. That paper is seminal because it goes through the elevations and we can do gene sequence heat maps as well. And we can see which genes are being turned on and turned off, which inflammatory pathways are turned on and off.
[00:05:44] You can see, your CD4 counts go down your CD8 counts go down. The inflammatory pathway genes within these inflammatory cells all get altered as well. So, I mean, this adds up to multiple problems and I’m going to get to that in just one [inaudible] producing genes go up, inflammatory respiratory cytokines go up, T and alpha signaling, NF-kappa beta signaling.
[00:06:13] So this is some of the more complex stuff we can see in a lab in and sequencing. But these are the first inoculations [inaudible] gene expression, downregulation of certain genes, upregulation of others persists for weeks. This one’s 24 days after one shot. So you can imagine what happens after a second then what happens after a booster.
[00:06:34] So we are continuing to dysregulate the immune system over time by doing this. Maybe many of you saw Dr. Gundry’s paper on the pulse score. Now the pulse score measures endothelial inflammation. So to Dr. Burkhardt’s photos where you see all those lymphocytes within the vessel walls. These markers of endothelial inflammation measure cardiac risk over time.
[00:06:57] But not just cardiac risk. It’s inflammatory milieu, inflammatory debris, inflammatory irritation in the blood vessel wall throughout the body. So, you know, on the left, you’ve got your arterial injury, cell proliferation, stimulation of new blood cells. Then you get adhesion, platelets, et cetera. So these processes can happen anywhere in the body.
[00:07:17] And that pulse score is really looking at markers of inflammation, apoptosis, thrombosis, vascular remodeling. And then they’ll predict over time, your cardiac risk. But it also indicates throughout the body, as the virus binds [inaudible] CD14, for example, and peristalsis in the myocardium. The virus, the spike, can get into these [inaudible] inflammation. The shots, based on all those heat maps from the genes from serum studies show that over time we have chronic elevated inflammatory shifts in the body.
[00:07:55] Now many have seen this paper by Dr. Fohse out of the Netherlands. This is critical as well. So not only are we looking for, you know, spike protein deposited in tissues, I’m looking at tumors right now, [inaudible] deposition within those tumors. But the other important thing is the shots are down-regulating our toll-like receptors that keep other viruses in check.
[00:08:14] So in addition in the blood, if we’re just looking for the patient got a shot, they’ve got elevated D-dimer or some of those other things I listed before. The other thing we need to look for, especially in the patients that have persistent long haul like symptoms just from the shot, activation of underlying latent viruses. The shots turned down our innate immune system’s ability to fight off latent infections within the body, especially the herpes family. Epstein BARR is one.
[00:08:41] I personally, after Covid, I had reactivated mono. But I know many patients after the shot, they complain of the chronic fatigue. I think it behooves us to check antibody panel for Epstein-Barr virus, amongst others. Also I’m looking at, you know, the toll-like receptors in relation to cancer upregulation.
[00:09:00] Some of the more [inaudible] ones, antiphospholipid antibodies have been elevated in many patients. So now you have a thrombophilic state.
[00:09:07] We’ve seen that the shots not only can have B and T cell dysregulation, but the important thing is your interferon alpha is critical for fighting off any virus and your interferon alpha is hijacked by the virus itself, but the shot can do that as well. So without your interferon, alpha interferon gamma type one interferons, you aren’t able to mount a response or a fight against most infectious invaders. So knowing that your interferons are being interfered with is important as well.
[00:09:38] Many papers in that one heat map. One showed down regulation [inaudible] ratios from T killer cells. Other esoterica. Many of us have had heard about vaccine induced thrombotic thrombocytopenia. So in some of these patients, they get the shot, we need to check them for a platelet factor number four antibody, anti-phosophilipid syndrome antibodies. We can also see some cancer associated thrombosis, rare markers, which becomes a little more esoteric. But we know the shots themselves can cause numerous types of clotting disorder, thrombosis, you know, with thrombocytopenia, etc.
[00:10:15] I mean, the list is endless and Dr. Risch and Battacharya emphasized in one of their papers, you know, to vaccinate the Covid recovered is scientifically incoherent because everything I just listed above can be accentuated by the shot, can be accentuated by the fact that one has already been exposed to immune response, a shot thereafter matters.
[00:10:37] Now, a question that’s important for me, is Omicron a game-changer? Well, in my mind, it is, it is sequentially different enough. It’s not binding in the [inaudible] receptor, it’s binding more to the ACE2, it’s staying more in the upper airways.
[00:10:51] Getting a shot to try to prevent Omicron based on all the things Dr. Burkhardt shared with us based from around the world in terms of adverse reactions and injury, Omicron being mostly a cold for most people, the risk benefit is now definitely upside down. You know, why would we be giving a shot for something that’s a toxic spike shot? And that spike protein, like Dr. Chetty mentioned, is toxic.
[00:11:17] And so to give it for a common cold, we’re putting people at more risk for harm than we are for benefit. So I will end there and go on questions.
[00:11:31] Shabnam Palesa Mohamed: Thank you very much, Dr. Ryan Cole for that brilliant exposition of pathology, the proof is in the blood. Dr. Mark Trozzi, questions for Dr. Ryan Cole, please.
[00:11:44] Dr. Mark Trozzi: Okay, yes, Dr. Cole and again, thank you. It’s such a lineup of a superheroes for me today. Thanks for everything you’ve been doing. We’ve been in your classroom even when you don’t see us. So thanks so much.
[00:11:56] I have a question here from Megan. What is the cause of the lymphocyte blood count being low and the CRP being elevated?
[00:12:05] Dr. Ryan Cole: That’s a good question. Most viral infections, usually post-infection, we’re going to see a lymphopenia. Now, part of that lymphopenia has to do with [inaudible] so basically the T cells go to sleep. So your initial interferon pathways want to turn, normally in a viral infection, want to turn on? Well, SARS-CoV-2 is very sneaky in that it sneaks in and says to those cells go to sleep. So when those pathways are impacted by the virus, those cell counts that you would want to go up slightly and fighting off an infection are subverted by the virus proper.
[00:12:47] We [inaudible] study out of Karolinska or I’m not, I’m not, don’t quote me on this study with the [inaudible] gene repair in vitro study, the virus itself can get in DNA and inhibit DNA repair mechanisms. That’s a problem. So these cell lines, your, your CD fours and eights can both be inhibited by virus if it gets into the nucleus.
[00:13:12] So now those cells aren’t replicating at the rate you need and fighting off an infection. So it’s multifactorial. It’s interferon downregulation, it’s viral disruption of genetic material, it’s basically viral overwhelm. Now, C-reactive protein is a protein that’s, I usually do the CRP high sensitivity in the lab. It’s basically a general marker of inflammation across many cell lines. And so when that type of protein is present, you know, you can see it in not just SARS-CoV-2, but it’s a good indicator of infection. It’s one of your acute phase reactants, your ferritin, your CRP, et cetera. So, just things we measure. I think, you know, the thing to be determined is how long these important cell lines stay suppressed.
[00:14:01] And that’s a concern I saw almost a year and a half ago. Just in the Covid recovered patients, that those cell lines were staying suppressed. But now, now in the vaccinated, we know that Dr. Chetty is absolutely. So now we need to be monitoring these patients. Are we able to bring those counts back up? Are we doing things clinically to intervene, to try to re stimulate cell and bone marrow production to get our, our thymus gland? And that’s where most of our cells are trained [inaudible]. There’s some interesting esoteric, again, that’s an alpha one, thymus, and beta, things like [inaudible] peptides.
[00:14:43] You know, one of the most important things, and you’ve heard me talk about it a billion times, vitamin D is critical for T-cell up-regulation and function. Low dose selenium or three or four Brazil nuts a day, if you like to eat Brazil nuts. Adequate levels of zinc. There’s so many trace minerals that are in the diet here in [inaudible]. Not having adequate minerals for enzymatic reactions, then cell lines [inaudible] to their appropriate levels. So nutritional medicine is a critically important aspect of getting back to health.
[00:15:15] I think following these patients to see when their counts do and don’t go back up is critical. Because these patients are appearing to be chronically immune suppressed. Now, the suppression of these cell lines goes to Dr. Burkhardt’s finding. We’re seeing, you know, these atypical lymphocytes run amok [inaudible] in these vaccinated patients. So we are running in to do right. And I think he and I, and other pathologists, we’re still trying to find out it’s multifactorial, its the multivariated equation. And there’s no one easy answer as to all of it. Obviously the spike is doing a lot of these things. I don’t have all the answers and that’s why we’re all looking and still trying to find out. So I’m grateful to be with such smart colleagues here today, and we’re just trying to study those and find them out.
[00:16:00] Dr. Mark Trozzi: Excellent. Thank you very much. Shabnam, do I have time for two or three more questions?
[00:16:06] Shabnam Palesa Mohamed: Yes, we do actually. We have five minutes.
[00:16:09] Dr. Mark Trozzi: Okay. Well, I’d like to ask a couple briefly, and then I see Dr. Edeling has his hand up for question. So the first one, in brief, which comes from Rena Los is with these injections, and I avoid the word vaccine for a good reason, with these injections, having their effect of suppressing the capacity of the innate immune system, Rena’s asking, do we see this similar effect with classical vaccines? And if not, what, what element, whether it be the MRA or the spike protein do you think is suppressing the innate immune system.
[00:16:45] Dr. Ryan Cole: Generally, we don’t see this with traditional vaccines. I want to throw in a caveat. Everybody asks about, well, what if we do a traditional SARS-CoV-2 vaccine? I still say bad idea because the family of coronaviruses always mutates.
[00:16:59] You give one protein now and down the road you’re going to end up with a bad antibody to a future coronavirus. So certain families of viruses [inaudible] against, that’s just basic biology. So in terms of the mechanisms, yes, I think you are correct. That paper by Dr. Fohse out of the Netherlands goes into this quite well.
[00:17:20] And I think these gene-based modality injections, yes, I hesitate to call them vaccines because they’re certainly not acting as a vaccine. As we can see they don’t prevent transmission, disease, death, cause higher rates of all cause mortality, et cetera. Yes, those mechanisms are suppressing. And this is again, I could a two hour lecture just on toll-like receptors, the mRNA is made to bypass certain ways in the immune system that pseudo uridine is inserted in there to be a ghost. RNA gets broken down in the body very easily, all day long. This was made such that it wouldn’t now because [inaudible] there’s [inaudible] altering toll-like receptor activity. That’s why we’re seeing an uptick in other viruses.
[00:18:08] I have an autopsy coming from a nine year old. Got his second shot, passed away in his sleep, encephalitis, myocarditis, we’ll be looking at some of the same things Dr. Burkhardt looked at. But the important thing I’ll look at in a deposition is, with immunohistochemical stains, I’m going to look for, in the encephalon we’ll be looking for other activated viruses. Did he have an herpes encephalitis of some toward triggered by immune suppression from that RNA down regulated genes down regulated pattern receptors that train our T cells to be on or off. So there’s, again, multiple things. We haven’t seen these with other protein based vaccines. But this is, I think the word of caution to humanity, large companies want to roll forward with an experimental modality and we haven’t done this widely before, and I think we’re looking at a humankind mistake worldwide.
[00:19:06] Shabnam Palesa Mohamed: Dr. Edeling, who was one of our speakers earlier on, did have a hand raised earlier. I know all of our questions are going to Q&A. But I suppose, because he was one of our speakers, we will grant him that exception. Dr. Edeling, your question.
[00:19:21] Herman Edeling: Thank you very much, Shabnam. I’ll be brief. Dr. Cole, I want to thank you for the tremendous honor of being able to speak to you in a meeting. A lot of my understanding of Covid and of the effects of these mRNA injections come from watching video recordings of your lectures, which I really wish to thank you.
[00:19:39] The slide presentation you’re showing us, there’s a tremendous amount of information in there that will be of help for us in determining vaccine causation in South African courts. And I want to ask you if we can have a copy of your slides and of course, from there, we can get to the articles that you’ve referenced. Thank you.
[00:19:57] Dr. Ryan Cole: Absolutely. Yeah. Yeah. It’s very information rich and I will forward those to Shabnam so she can get them to you or you can reach out to me directly as well. So I will absolutely get those to you because these are very critical, critical factors in the blood to look at.
[00:20:14] Herman Edeling: Yeah, that will be perfect, Dr. Cole, she’ll give them to us.
[00:20:18] Dr. Ryan Cole: We’ll do thank you.
[00:20:20] Shabnam Palesa Mohamed: Thank you doctors. Last question from one of our speakers, Megha Verma, very quickly.
[00:20:26] Megha Verma: Hi Ryan. Thank you for an amazing presentation. It was very informative. I have a very quick question that links your presentation to Dr. Edeling’s presentation. You mentioned the Bradford Hill’s criteria for causation, how would they connect to the like three types of scientific evidence or like the four levels of scientific evidence that Dr. Edeling presented, which was the randomized control trial and then there’s like two more that were different types of experiments and the last one was experts. So how do you think it would fit in with those classes of evidence?
[00:21:05] Dr. Ryan Cole: I think it can apply to any of those categories to be quite honest. And I think, I think the thing we’ve let go by the wayside this year is all [inaudible] and most, most great discoveries in the world are accidents. They’re observational. That’s where I saw something [inaudible] in the lab viral bumps.
[00:21:29] Dr. Burkhardt saw that inflammation on autopsy. Observation starts first. Then you form your hypothesis. Then you apply the scientific experiment to it. Then you repeat it and then you draw your conclusions. But you know, meta analytical data, waiting for a randomized controlled trial is a pandemic is foolishness.
[00:21:47] So I think the aggregate of these findings,and you don’t have to have all a Bradford’s criteria to push you in the right direction of, Hey, we have a signal here, we have an answer. No correlation is not causation, but when you have so much correlation within all of those categories, be it in an RCT, be it observational, be it meta analytical. I think you can apply it across all of the categories. And I think it takes an astute mind, an observer to say, look, I don’t need to wait for that other when harm is being done now. So, I think you apply it situationally.
[00:22:24] Megha Verma: Thank you
[00:22:25] Dr. Ryan Cole: Thank you. My pleasure.
[00:22:26] Shabnam Palesa Mohamed: One last one, before we let you go, Ryan. I should have asked you this in the beginning, your thoughts on why this causation conference bringing together multidisciplinary experts and advocacy groups is so important.
[00:22:38] Dr. Ryan Cole: I think this is critical because not everybody practices the same area of medicine and elephant, trying to describe the part that they’re feeling, but they don’t have a fair and bringing together.
[00:22:57] Shabnam Palesa Mohamed: Ryan, can I ask you to please switch your camera off so we can hear you clearly. Thank you so much.
[00:23:02] Dr. Ryan Cole: Sorry about that. Yeah. I’m in a snow storm right now. The signal was a little bad, but it’s the blind men describing the [inaudible] we’re all here for areas of expertise. And when the blind men are touching a part of the elephant and one things that feels like a hose and other feels like a tree trunk and other fields like a hard, you know, toenail or bone, they don’t see the whole elephant. And so this is all the blind men trying to describe the elephant. But when we all come together, we’re no longer blind because we put all our descriptions together, one coherent picture.
[00:23:38] So when we bring expertise from practice, when we bring expertise from the lab, when we bring expertise from those who don’t practice medicine that are in the legal fields and the philosophical fields, I think that aggregate, it brings together a greater body of knowledge and energistic. And so causation is much more provable when you have great minds bringing their angle and philosophy and aspect of the whole picture together into one great whole.
[00:24:06] Shabnam Palesa Mohamed: Thank you very much Dr. Ryan Cole, of course, to Dr. Katrina Lindley, who are helping us invite you to this particular conference. And as we say goodbye, we remind you of a phrase that you’ll probably resonate with. Courage is contagious. We hope to see you at the next Understanding Vaccine Causation Conference. Take care.
[00:24:24] Dr. Ryan Cole: Thank you very much.